Biophysical Basis of Therapeutic Resistance

T cell-based immunotherapies have shown striking efficacy in treating blood cancers; however, relapse occurs in a significant number of patients. There is growing evidence that mechanics plays a key role in T cell-mediated cytotoxicity. To better understand this interaction and characterize the physical mechanisms of therapeutic resistance, we are performing high-throughput measurements of cancer cells' biophysical properties in collaboration with the Manalis Lab at MIT.